In Hubei Ezhou, the main differences between a social security base of 6,600 yuan and 5,000 yuan are as follows:

1. Payment amount: Social security contributions are calculated as the product of the base and the contribution rate. For instance, if the pension insurance contribution rate is 20% (for self - employed individuals), when the base is 6,600 yuan, the monthly pension insurance payment is ​
   ×20%=
   yuan; when the base is 5,000 yuan, the monthly payment is ​
   ×20%=
   yuan. The higher the base, the more one pays in all types of social security contributions (including pension, medical, unemployment, work - injury, and maternity insurance).

2. Pension benefits in the future: Pension calculation is related to the payment base. A higher payment base like 6,600 yuan indicates more contributions during the payment period. According to the pension calculation formula, other factors being the same, the pension amount received after retirement will be higher. The pension is calculated based on factors such as the average social wage in the province during the retirement period, the individual's payment index (related to the payment base), and the payment period. A higher base can increase the individual's payment index, thereby increasing the calculated pension amount.

3. Medical insurance benefits: Although the reimbursement ratio of medical insurance is mainly determined by policy regulations, the medical insurance account allocation may be affected by the payment base. A higher base like 6,600 yuan may result in a larger amount being allocated to the personal medical insurance account, which can be used for purchasing medicines in pharmacies, paying for outpatient medical expenses, etc.

4. Impact on other insurances: For unemployment insurance, work - injury insurance, and maternity insurance, the higher the payment base, the more insurance premiums the employer pays (for employees), and in case of corresponding insured events, the benefits obtained may also be different. For example, in the case of work - injury insurance, the compensation amount may be related to the payment base to a certain extent.

In general, choosing a higher social security base like 6,600 yuan means paying more in the short term, but it can bring relatively higher benefits in pension, medical insurance, and other aspects in the long term. When choosing a social security base, individuals should comprehensively consider their economic affordability and future benefit expectations.